FUNCTIONAL ANALYSIS OF VARIANTS IN COMPLEMENT FACTOR I IDENTIFIED IN AGE-RELATED MACULAR DEGENERATION AND ATYPICAL HEMOLYTIC UREMIC SYNDROME

Functional Analysis of Variants in Complement Factor I Identified in Age-Related Macular Degeneration and Atypical Hemolytic Uremic Syndrome

Complement factor I (FI) is a central inhibitor of the complement system, and impaired FI function increases complement activation, contributing to diseases such as age-related macular degeneration (AMD) and atypical hemolytic uremic syndrome (aHUS).Genetic variation in complement factor I (CFI) has been identified in both AMD and aHUS, with more t

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Anti-inflammatory activities of dichloromethane-methanolic leaf and stem bark extracts of Ximenia americana in mice models

Introduction: Ximenia americana is a highly branched shrub mainly found in tropics of Asia, Africa, New Zealand, Central and South America among others.In most parts of Africa, X.americana is used in folklore to treat various disorders such as oedema, pain, fever, helminthiasis, diarrhea and burns among others.There is no published data on anti-inf

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